SUSAN FRIEL GRAMMER

Western Michigan University, Department of Geosciences

Michigan Geological Repository for Research and Education

Kalamazoo, MI 49009

(269) 387-8642, susan.grammer@wmich.edu

___________________________________________________________________________________

Summary

· Founder and Coordinator of K-12 geosciences outreach program (2006-2008)

· Science and medical writing experience (1998-2005) for both scientists and the public.

· Basic and applied biomedical research in cellular and molecular immunology, microbiology, and oncology (1978-1996).

· B.S. Microbiology, 1979, University of South Florida.

· Graduate level courses in Immunology 1983, University of Colorado Health Sciences Center.

· Elected to American Association of Immunologists, 1987.

· Member, National Association of Science Writers

· Member, American Medical Writers’ Association

· Member, Association for Supervision and Curriculum Development

· Member, National Science Teachers’ Association and National Earth Science Teachers’ Assoc.

· Member, Michigan Science Teachers’ Association and Michigan Earth Science Teachers’ Assoc.

· Member, Geological Society of America

Biomedical Research Experience

1995-1996

UNIVERSITY OF MIAMI SCHOOL OF MEDICINE, Miami, FL

Research Associate, Department of Microbiology and Immunology

P.I. – Richard L. Riley, Ph.D.

Studies on B cell development and function in graft-versus-host disease

1993-1995

BAXTER DIAGNOSTICS/DADE INTERNATIONAL, Miami, FL

Associate Research Scientist, Cellular and Molecular Immunology

P.I. – Hing Wong, Ph.D.

Analysis of functional properties of recombinant T-cell receptor and MHC proteins in cellular systems measuring antigen presentation. Co-author of initial business plan for spin-off biotechnology company.

1987-1993

UNIVERSITY OF MIAMI SCHOOL OF MEDICINE, Miami, FL

Research Associate, Department of Microbiology and Immunology.

P.I. - J.Wayne Streilein, M.D.

Studies to assess antigen presentation in epidermal dendritic cells and the effects of various cytokines on antigen presentation.

1983-1987

NATIONAL JEWISH CENTER FOR IMMUNOLOGY AND RESPIRATORY MEDICINE, Denver, CO

Laboratory Researcher, Dept. of Basic Immunology

P.I. – Robert W. Chesnut, Ph.D.

P.I. -- Howard M. Grey, M.D.

Studies on B-cell antigen presentation and studies to elucidate HSV T-cell epitopes.

1980-1982

WADLEY INSTITUTES OF MOLECULAR MEDICINE, Dallas, TX

Research Assistant, Dept. of Allergy and Immunology

P.I. – Amanullah Khan, M.D.

Generation of monoclonal antibodies to tumor associated antibodies and assessment of cellular immune function in cancer and HIV patients.

1979-1980

UNIVERSITY OF SOUTH FLORIDA SCHOOL OF MEDICINE, Tampa, FL

Laboratory Technician, Dept. of Microbiology and Immunology

P.I. – Steven Spector, Ph.D.

P.I. – Herman Friedman, M.D.

Natural killer cell assays, other assays of cellular immune function

1978-1979

UNIVERSITY OF SOUTH FLORIDA, Tampa, FL

Undergraduate Research Assistant, Dept. of Biology

P.I. – Daniel V. Lim, Ph.D.

Group B Streptococcus infections in neonates

1977-1978

UNIVERSITY OF SOUTH FLORIDA, Tampa, FL

Undergraduate Research Assistant, Dept. of Biology

P.I. –Dr. Norvall McClung

Maintenance of Nocardia Type Culture Collection

Science Communications Experience

2003/2004

NOVARTIS PHARMACEUTICALS, Pathways: The Novartis Journal

• “Projections of progress: the evolving landscape of the battle against cancer”, Pathways: The Novartis Journal, 5(1): 5-11, Feb. 2004.
• “ADHD: Fact or Fiction?” Pathways: The Novartis Journal, 4(2): 4-9, April/June 2003,

2000-2003

MD Anderson Cancer Center, Houston, TX

Jack Roth, M.D.

Dept. of Thoracic and Cardiovascular Surgery and Program in Gene Therapy

· 2000-2003: Co-author, textbook chapters and review articles; editor/writer, research articles.

· 2001: Design and drafting of GLP and GMP compliant SOPs for associated academic laboratory involved in production of gene therapy product for clinical trials.

1999

N. Jones, M.D., Dept. of Gynecologic Oncology

· Ghostwriter, 1999: grant proposal on breast cancer and nutrition

E. Holland, M.D., Dept. of Neurosurgery

· Ghostwriter, June-Sept. 1999: Two projects on molecular genetics of brain tumors

1999-2002

AMERICAN CHEMICAL SOCIETY, Washington, DC

· “Focusing on Hyperactivity: New diagnostic tools may show us that there is more to ADHD than meet the eye”, Today’s Chemist at Work, Vol. 11, No. 3, March 2002, p.41.

· “Making Drugs Take the Heat”, Modern Drug Discovery, Vol. 2, no.6, Nov/Dec 1999.

· “New Genes Restore ‘Heart’ to Failing Hearts”, Modern Drug Discovery, April 2000.

· “Intolerant Mice Provide Clues to Multiple Sclerosis”, Modern Drug Discovery, April 2000.

· “Curtailing Colorectal Cancer: Early diagnosis and genetic counseling are proving effective”, Modern Drug Discovery, May 2000.

· “Synaptic Musings”, Modern Drug Discovery, Jan 2001.

· “A Probe for Pregnancy Complications”, Modern Drug Discovery, March 2001.

· “Needles Made Needless”, Modern Drug Discovery, March 2001.

2000/2001

Introgen Therapeutics, Houston, TX

· Consulting Science Writer, Editing services.

1999

Howard Hughes Medical Institute, Office of Communications, Chevy Chase, MD

· “The Why Behind Excessive Alcohol Consumption”, HHMI Quarterly Bulletin, June 1999.

· “Transcription Factor, p63, Is Critical in Embryogenesis”, HHMI Quarterly Bulletin, 1999.

Other Experience

WESTERN MICHIGAN UNIVERSITY, DEPARTMENT OF GEOSCIENCES, Kalamazoo, MI

MICHIGAN GEOLOGICAL REPOSITORY FOR RESEARCH AND EDUCATION, 2006-2008

• Founder and Coordinator of MGRRE K-12 Outreach Program, Core Kids

MICHIGAN ALLIANCE FOR GIFTED EDUCATION

• Editor, IMAGES, newsletter of organization

• Board of Directors, 2002-2005,
• Regional Representative, 2003-2004

MATTAWAN CONSOLIDATED SCHOOL, Mattawan, MI

• Initiated and coordinated Later Elementary campus Midwest Talent Search (MATS) program

GIFTED EDUCATION PRESS QUARTERLY, Manassas, VA

• Article published: “It Depends,” Winter 2004.
• Article published: “Identification and Education of Young Gifted Children”, March 2001

TEXAS ASSOCIATION FOR THE GIFTED AND TALENTED, Austin, TX

· Invited Speaker, TAGT 24^th Annual Professional Development Conference for Educators and Parents. “To Be or Not To Be ‘Gifted’: Unmasking Young Gifted Children”. Dec. 2001.

National Organization of Mothers of Twins Clubs

· “Working MOMs” Chapter in NOMOTC Guide to Raising Multiples, Harpeth House Publishing, 2002, p. 202-227.

KATY INDEPENDENT SCHOOL DISTRICT, Katy, TX

· Judge: 1999, 2000, 2001 Scholastic Writing Competition District Finals

· KISD Gifted and Talented Program “SuperSaturday”. “Spy Kids Crack the Genetic Code”

FORT BEND INDEPENDENT SCHOOL DISTRICT, Sugarland, TX, GT Program

Judge, Genetics Project: “Mentoring in Education” Final Project Presentations, May 2001

Bibliography

BOOK CHAPTERS AND REVIEW ARTICLES

(With Jack A. Roth, MD, MD Anderson Cancer Center, Houston, TX)

Roth, J.A. and S.F. Grammer (2004). Gene replacement therapy for non-small cell lung cancer: a review, in Hematology/Oncology Clinics of North America, LUNG CANCER PART I: Radiotherapy and Chemotherapy in Locally Advanced NSCLC, 18(1):215-29.

Roth, J.A., and S.F. Grammer (2004). Tumor suppressor gene replacement for cancer in Cancer Gene Therapy, Curiel and Douglas, eds, Human Press.

Roth, J.A., and S.F. Grammer, (2003). Tumor suppressor gene therapy in Methods in Molecular Biology, Tumor Suppressor Genes: Vol. II, Regulation, Function and Medicinal Applications. W. El-Deiry, ed., Humana Press, Totowa, NJ, p 577-598.

Roth, J.A., S.F. Grammer, J.A. Merritt, and S.G. Swisher (2003) Gene therapy clinical trials for cancer: Replacement of tumor suppressor gene p53, in Gene Therapy: Therapeutic Mechanisms and Strategies, N. Templeton, ed., Marcel Dekker.

Roth, J.A., and S.F. Grammer (2001) Gene therapy: tumor-suppressor gene replacement and oncogene suppression, in The Cancer Handbook, Vol. 2, Macmillan Publishers Ltd.

Roth, J.A., S.F. Grammer, S.G. Swisher, et al. (2001) Gene therapy approaches for the management of non-small cell lung cancer, in Seminars in Oncology, 28 (4 sup 14):50-56.

Roth, J.A., S.F. Grammer, S.G. Swisher, J. Nemunaitis, J. Merritt, R.E. Meyn. 2000. Gene replacement strategies for treating non-small cell lung cancer in Semin. Radiation Oncol. 10(4):333-342.

Roth, J.A., S.F. Grammer, S.G. Swisher, R.Komaki, J. Nemunaitis, J. Merritt, and

Raymond Meyn, Jr. P53 (2000)Gene replacement for cancer: Interactions with DNA damaging agents, in Acta Oncologica, 8.

Roth, J. A., S. F. Grammer, S. G. Swisher, R. Komaki, J. Nemunaitis, J. Merritt, T. Fugiwara, R.E. Meyn (2000) Current Perspectives in the Treatment of Lung Cancer: Gene Therapy Approaches for the Management of NSCLC, in Proceedings of Symposium

(with J. Wayne Streilein, M.D., University of Miami School of Medicine)

Grammer, S.F. and J.W. Streilein (1994). The immune system in cutaneous disease: The search for a mouse model of the immunopathology of psoriasis. In: Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools, J. Sundberg, ed. CRC Press, Boca Raton.

Streilein, J.W., S.F. Grammer, T. Yoshikawa, A. Demidem and M. Vermeer (1990). Functional dicotomy between Langerhans cells that present antigen to naive and to memory/effector T lymphocytes. Immunological Reviews, 1990, 117:159-183.

PEER REVIEWED RESEARCH ARTICLES

Kurimoto, I., S.F. Grammer, T. Shimitzu, T. Nakamura and J.W. Streilein. 1995. Role of F4/80+ cells during induction of hapten-specific contact hypersensitivity. Immunology. 85(4):621-629.

Dai, R.P., S.F. Grammer and J.W. Streilein. 1993. Fresh and cultured Langerhans cells display differential capacities to activate hapten-specific T cells. J. Immunol. 150:59-66.

Demidem, A., J.R. Taylor, S.F. Grammer and J.W. Streilein. 1992. Effects of chloroquine on antigen presenting functions of epidermal cells from normal and psoriatic skin. J. Invest. Dermatol. 98:181-186.

Demidem, A., J.R. Taylor, S.F. Grammer and J.W. Streilein. 1991. T lymphocyte activation properties of epidermal antigen presenting cells from normal and psoriatic skin. Evidence that psoriatic epidermal antigen presenting cells resemble cultured normal Langerhans cells. J. Invest. Dermatol. 97:454-460.

Demidem, A., J.R. Taylor, S.F. Grammer and J.W. Streilein. 1991. Influence of microenvironmental factors on human Langerhans cell function in vitro. Regional Immunology 3: 297-304.

Demidem, A., J.R. Taylor, S.F. Grammer and J.W. Streilein. 1991. Comparison of effects of transforming growth factor-beta and cyclosporin A on antigen presenting cells of blood and epidermis. J. Invest. Dermatol. 96:401-407.

Grammer, S.F., A. Sette, S. Colon, L.Walker and R. Chesnut. 1990. Identification of an HSV-1/HSV-2 cross-reactive T cell determinant. J. Immunol. 145:2249-2253.

Streilein, J.W. and S.F. Grammer. 1989. In vitro evidence that Langerhans cells can adopt two functionally distinct forms capable of antigen presentation to T lymphocytes. J. Immunol. 143:3925-3933.

Grammer, S.F., G.Y. Ishioka and R.W. Chesnut. 1988. Studies on the capacity of B cells as well as T cells to serve as accessory cells for the activation of Herpes Simplex Virus-specific cytolytic T cells. J. Immunol. 140:2016-2022.

Coeshott, C., R.W. Chesnut, R.R. Kubo, S.F. Grammer, D.M. Jenis and H.M. Grey. 1986. Ia-specific mixed leukocyte reactive T cell hybridomas: Analysis of their specificity by using purified Class II MHC molecules in a synthetic membrane system. J. Immunol. 136:2832-2838.

Krieger, J.I., S.F. Grammer, H.M. Grey and R.W. Chesnut. 1985. Antigen presentation by splenic B cells. Resting B cells are ineffective whereas activated B cells are effective accessory cells for T cell response. J. Immunol. 135:2937-2945.

Khan, A., S. Grammer, D. Chang, N. Hill and J. Miller. 1983. Mouse monoclonal antibody (WI-MN-1) against malignant melanoma. Cancer Res. 43:5868-5871.

PATENTS

Co-inventor on patent: Monoclonal antibody WI-MN-1, Wadley Institutes of Molecular Medicine, 1985.

Co-inventor of, and co-author of patent application: MHC fusion complexes and uses thereof, 1996.

ABSTRACTS AND PRESENTATIONS

Grammer, S.F., C.M. Abolafia and J.W. Streilein. 1992. Tumor necrosis factor-alpha alters neither antigen processing or presentation by Langerhans cells (abs). J. Invest. Dermatol. 98:592. Meeting of the Society for Investigative Dermatology, Baltimore, MD.

Grammer, S.F., A. Demidem, J.R. Taylor and J.W. Streilein. 1991. Concerning the cells responsible for T cell activation in psoriatic epidermis (abs). J. Invest. Dermatol. 96:625A. Meeting of the Society for Investigative Dermatology, Seattle, WA.

Grammer, S.F., C.M. Abolafia and J.W. Streilein. 1991. Effects of gamma irradiation on sensitivity of antigen presenting cells (APC) to transforming growth factor-beta (abs). FASEB Journal 5:A628. Meeting of the Federation of American Societies for Experimental Biology, Atlanta, GA.

Grammer, S.F., D.A. Hamilton and J.W. Streilein. 1990. The role of GM-CSF in the acquistion of unique functional properties by epidermal Langerhans cells (abs). Miami Biotechnology Winter Symposium, Miami, FL.

Streilein, J.W. and S.F. Grammer. 1989. Evidence that Langerhans cells can exist in two different states of functional activity with respect to antigen presentation (abs). J. Invest. Dermatol. 92:523. Meeting of the Society for Investigative Dermatology, Washington, DC.

Grammer, S.F. and J.W. Streilein. 1989. Fresh and cultured Langerhans cells present antigen equally well to primed T cells, but only the latter present antigen to unprimed T cells (abs). J. Cellular Biochem., supp. 13A:300. UCLA Symposia on Molecular and Cellular Biology: Immunogenicity, Steamboat Springs, CO.

Grammer, S.F. and R.W. Chesnut. 1987. B cells as APC for the generation of MHC Class I-restricted virus specific CTL (abs). Meeting on Antigen Presenting Cells, Richmond, VA.

Chesnut, R.W., P. Berman and S.F. Grammer. 1987. HSV gD specific T cells recognize an epitope generated by antigen processing that is expressed on both HSV-1 and HSV-2 infected APCs (abs). Meeting of the Federation of American Societies for Experimental Biology, Washington, DC.

Khan, A., S. Grammer and N. Hill. 1982. Monoclonal antibody against malignant melanoma (abs). Eighth International Convocation on Immunology, Buffalo, NY.

Lim, D., M. Marnell and S. Friel. 1980. Confirmatory identification of Group D Streptococci by slide agglutination (abs). Meeting of the American Society for Microbiology, Miami, FL.

Lim, D., S. Friel and M. Marnell. 1980. Rapid confirmatory identification of Group B Streptococci (abs). Meeting of the American Society for Microbiology, Miami, FL.